The PROTEOSTEM lab is led by Dr. William Grey at the University of York.

We focus on the role of protein homeostasis – so called “Proteostasis” – in healthy and malignant stem cell development.
The predominant focus of the lab is the haematopoietic (blood) system and cancerous transformation to acute myeloid leukaemia (AML).


Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Tsutsumi et al. (2023) Cell

The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function

Grey et al. (2023) Hemasphere

CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia

Grey et al. (2022) Science Translational Medicine


We thank all our funders, patients and advocates for supporting work in the ProteoStem lab.

The ProteoStem lab is supported by the following grants:

Medical Research Council Career Development Award.

John Goldman Fellowship from Leukaemia U.K.

European Haematology Association Bilateral Collaborative Grant

Children’s Cancer and Leukaemia Group Little Princess Trust Grant

National Mouse Genetics Network (MRC) Director’s Award.

Clinical Academic Research Partnership (MRC) Award.

Lady Tata Memorial Trust Grant


4 Fully Funded PhDs advertised now

Interested in doing a PhD with the ProteoStem group? We have 4 fully funded PhD positions available starting in 2024. See here for details: https://x.com/Bill_G_Grey/status/1717908866686484715?s=20

Welcome Max

Welcome to Max Ter-Grigoryan who is joining us for their intercalating Master’s project. Max will be studying trafficking of proteins between the cytoplasm and nucleus in haematopoeitic stem cells. Max is on the lookout for PhDs, so get reach out at: [email protected] if you want a motivated student starting in 2024

Welcome Megan!

Welcome to Megan our new MRC DiMeN DTP PhD student. Megan joins us after completing her MRes in Liverpool and will be focusing on proteostasis in haematopoietic stem cells. Check out Megan’s bio on our Teams page.

Welcome Katie!

Today we welcome Katie Trueman to the Grey lab. Katie is joining us for a year to work on projects involving spectral unmixing flow cytometry and high parameter imaging. Check out Katie’s bio on our Teams page.

New publication!

We are proud to report that our latest work has been published in Cell. This work is a close collaboration with the Hitchcock lab at the University of York and collaborators at Stanford University (U.S.A.). Check our our new article: https://doi.org/10.1016/j.cell.2023.07.037